Vijayendran, Chandran; Barsch, Aiko; Friehs, Karl; Niehaus, Karsten; Becker, Anke; Flaschel, Erwin: Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling. In: GENOME BIOLOGY. Jg.9 H. 4. 2008, S. R72 ff.
Inhalt
- Background
- Results
- Metabolome profiling
- Gene expression profiling
- Extent of changes
- Direction of the observed extent of changes
- Gene-metabolite correlation network analysis
- Evaluation of evolution-specific networks
- Evolution-specific intersection networks
- Parallelism and functional relevance of molecular evolution
- Parallelism in outer-membrane protein expression
- Discussion
- Conclusion
- Materials and methods
- Strain and culture conditions
- Metabolite profiling
- Gene expression profiling
- Microarray data analysis
- Network analysis
- Network functional analysis
- Outer membrane protein analysis
- Abbreviations
- Authors' contributions
- Additional data files
- Acknowledgements
- References