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Janssen, Stefan ; Reeder, Jens; Giegerich, Robert: Shape based indexing for faster search of RNA family databases. In: BMC Bioinformatics. Jg.9 H. 1. 2008, S. 131 ff.
Inhalt
Searching with covariance models
Filtering
Basic concepts of filtering
BLAST-filter
HMM-filter
A new approach: shape based filtering
A review of abstract shapes of RNA
Methods
Shape-based indexing framework
Shape index construction
1-SS cons-shape-index: fss(f) = {p(SS_cons)}
1-consensus-shape-index: fss(f) = rankmin{>
1-hybrid-shape-index
union-shape-index: fss(f) = {p(RNAfold_
k-best-shape-index: fss(f) = [
Query shape spectrum construction
1-shape-spectrum: qss(x) = RNAshapes(1, p, x)
k-shape-spectrum: qss(x) = RNAshapes(k, p, x)
Using multi-level abstraction
Using folding energies
Omitting "difficult" families
Algorithm
Method of choice
Results and Discussion
Construction of a testing set
Testing
Conclusion
Table 1
Authors' contributions
Additional material
Acknowledgements
References