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Panhorst, Michael: On-chip manipulation and positioning of biomolecules with magnetic beads. 2005
Inhalt
Preface
Publications and Conferences
Basics
Biomolecules
Biotin
Avidin
Streptavidin
Ligand-Receptor bonds
Functionalised magnetic markers
Magnetic fields generated by conducting lines
Computer-simulations of the magnetic fields
Magnetic Tunnel Junctions
Tunneling effect
Tunnel Magneto Resistance
Exchange Bias
Preparation and analytical tools
Sputtering thin films
Ion beam milling
Optical lithography
E-beam lithography
Auger electron spectroscopy
Alternating Gradient Magnetometer
Optical microscope with a CCD-Camera system
On-chip manipulation of magnetic markers with conducting lines
Basic sample preparation
Problems during the measurements
Examples for on-chip manipulation with magnetic markers
Current through a straight line
Trapping markers in a ring
Manipulation using electric fields
Transportation and positioning of magnetic markers
Discussion
Bond-Force measurements
Sulfur-gold bond
Sample preparation for ligand-receptor bonds
Surface preparation
Selection of suitable magnetic markers
Bond enthalpy of all involved bonds
Results
Discussion
Exact positioning of single magnetic particles
Development of the lithographic design
Specialities regarding the measurement conditions
Results and discussion
A single magnetic particle on a TMR sensor
Development of the TMR-Stack
Sample preparation
Results
Discussion
Summary and Outlook
List of Figures
Bibliography
Acknowledgements