Schröder, Jasmin; Maus, Irena; Meyer, Katja; Wördemann, Stephanie; Blom, Jochen; Jaenicke, Sebastian; Schneider, Jessica; Trost, Eva ; Tauch, Andreas: Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of [...]. In: BMC Genomics. Jg.13 H. 1. 2012
Inhalt
- Background
- Results and discussion
- Pyrosequencing and annotation of the C. resistens DSM 45100 genome
- General architecture of the C. resistens DSM 45100 chromosome
- General metabolic features and lipophilic lifestyle of C. resistens DSM 45100
- Amino acid metabolism and utilization of histidine by C. resistens DSM 45100
- Detection of candidate virulence factors in the genome of C. resistens DSM 45100
- The penicillin-binding proteins and the quinolone-resistance-determining region of C. resistens DSM 45100
- The modular architecture of the multi-drug resistance plasmid pJA144188
- DNA modules of plasmid pJA144188 containing antibiotic resistance regions
- The class 1 integron of plasmid pJA144188 and its gene cassettes encoding aminoglycoside resistance proteins
- The tetracycline-minocycline resistance region of plasmid pJA144188
- Conclusions
- Methods
- Bacterial strains and growth conditions
- Genome sequencing of C. resistens DSM 45100
- Annotation and bioinformatic analysis of the genome sequence
- Antimicrobial susceptibility assays with tetracyclines and fluoroquinolones
- Cloning of the tet(W) gene from C. resistens DSM 45100
- RNA techniques and measurement of tet(W) transcript levels
- Acknowledgements
- Author details
- Authors' contributions
- References