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Sreij, Ramsia; Dargel, Carina; Schweins, Ralf; Prévost, Sylvain; Dattani, Rajeev; Hellweg, Thomas: Aescin-Cholesterol Complexes in DMPC Model Membranes: A DSC and Temperature-Dependent Scattering Study. In: Scientific Reports. Jg.9 H. 1. 2019
Inhalt
Results
Figure 2 DSC data: Endotherms for (a) the binary system DMPC/aescin and the ternary systems containing (b) 1 mol%, (c) 5 mol%, and (d) 10 mol% of additional cholesterol.
Differential scanning calorimetry (DSC).
Figure 3 DSC results.
Wide-angle X-ray scattering (WAXS).
Figure 4 WAXS curves.
Figure 5 WAXS results of samples with 10 mol% cholesterol: (a) Acyl chain correlation distances dWAXS obtained from peak positions in Fig.
Figure 6 SAXS form factors of DMPC SUVs and SUVs with additives.
Small-angle X-ray scattering (SAXS).
Figure 7 CMS fit results from the analysis of the SAXS curves in Fig.
Figure 8 Model-independent SAXS results for samples with 1 mol% aescin at 10 °C.
Small-angle neutron scattering (SANS).
Figure 9 SANS curves of samples with (a,b) 1 mol% and (c,d) 5 mol% cholesterol with aescin contents between 0–1 mol% at 10 °C (blue curves) and 40 °C (red curves).
Table 1 Results of the SANS data analysis.
Discussion and Conclusion
Methods
Materials.
Sample preparation.
Differential scanning calorimetry (DSC).
Small-angle and wide-angle scattering.
Wide-angle X-ray scattering (WAXS).
Small-angle X-ray scattering (SAXS).
Small-angle neutron scattering (SANS).
Acknowledgements