Hyseni, Mentor; Zumbrägel, Nadine ; Offermanns, Heribert; Gröger, Harald: Expanding the Scope of Asinger Chemistry towards Enantiomerically Pure Secondary Amines and β-Aminothiols through Chemoenzymatic Derivatization of 3-T [...]. In: Chemistry. Jg.2019 H. 1. 2019, S. 180-191
Inhalt
- Experimental
- General Information
- Construction and Preparation of Whole-Cell Catalyst
- 2,2,4,5,5-Pentamethyl-3-thiazoline (1)
- Achiral Gas Chromatography Analysis
- (S)-2,2,4,5,5-Pentamethyl-3-thiazolidine (2)
- N-Isopropyl-3-methylbutan-2-amine (rac-3)
- General Procedure 1 for Derivatization Using Phenylisocyanate
- Attempts for the Synthesis of (S)-3 According to Ni/Al Alloy Routes a–c
- Attempts for the Synthesis of (S)-3 by Using Raney Ni (W4)
- (S)-N-Isopropyl-3-methylbutan-2-amine (S-3)
- (S)-1-Isopropyl-1-(3-methylbutan-2-yl)-3-phenylurea (S-4)
- General Procedure 2 for Synthesis of -aminothiols
- S-(3-(1-Isopropyl-3-phenylureido)-2-methylbutan-2-yl)phenylcarbamothioate (rac-6)
- (S)-S-(3-(1-Isopropyl-3-phenylureido)-2-methylbutan-2-yl)phenylcarbamothioate ((S)-6)
- Chiral Supercritical Fluid Chromatography–High Performance Liquid Chromatography Analysis
- Results and Discussion
- Biocatalytic Synthesis of an Enantiomerically Pure Thiazolidine
- Reductive Desulfurization of Thiazolidine (S)-2
- Reductive Ring Opening Toward Synthesis of -aminothiols
- Conclusions
- References