The evidence about the impact of polyvictimization on suicidal ideation among adolescents in the Eastern Mediterranean region is limited. The purpose of this study was to explore the association between polyvictimization and suicidal ideation while considering the potential moderating effect of gender on that association among Emirati adolescents. Secondary data (N = 2520) from the Global School-based Student Health Survey were analyzed. Gender was found to be a significant effect modifier of the association between polyvictimization and suicidal ideation. Based on gender-specific multivariable logistic regression models, victimized females had higher odds of reporting suicidal ideation than their male counterparts after adjusting for known confounders such as risk behavior and factors related to mental health, peer relations, and lack of parental understanding. The results of this study could guide public health officials in recognizing the magnitude of victimization on the mental health of adolescents especially in females.