TY  - JOUR
AB  - The forced rupture of single chemical bonds in biomolecular compounds (e.g. ligand-receptor systems) as observed in dynamic force spectroscopy experiments is addressed. Under the assumption that the probability of bond rupture depends only on the instantaneously acting force, a data collapse onto a single master curve is predicted. For rupture data obtained experimentally by dynamic AFM force spectroscopy of a ligand-receptor bond between a DNA and a regulatory protein we do not find such a collapse. We conclude that the above mentioned, generally accepted assumption is not satisfied and we discuss possible explanations. (C) 2004 Elsevier B.V. All rights reserved.
DA  - 2004
DO  - 10.1016/j.biotec.2004.04.017
KW  - chemical reaction kinetics
KW  - single molecule force spectroscopy
LA  - eng
IS  - 1-2
M2  - 13
PY  - 2004
SN  - 0168-1656
SP  - 13-23
T2  - Journal of Biotechnology
TI  - Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-16066371
Y2  - 2024-11-21T23:21:16
ER  -