TY  - JOUR
AB  - Motivation: We present a new probabilistic model of the evolution of RNA-, DNA-, ol protein-like sequences and a software tool, Rose, that implements this model. Guided by an evolutionary tree, a family of related sequences is created from a common ancestor sequence by insertion, deletion and substitution of characters. During this artificial evolutionary process, the 'true' history is logged and the 'correct' multiple sequence alignment is created simultaneously The model also allows for varying rates of mutation within the sequences, making it possible to establish so-called sequence motifs. Results: The data created by Rose are suitable for the evaluation of methods in multiple sequence alignment computation and the prediction of phylogenetic relationships. It can also be useful when reaching courses in or developing models of sequence evolution and in the study of evolutionary processes.
DA  - 1998
DO  - 10.1093/bioinformatics/14.2.157
LA  - eng
IS  - 2
M2  - 157
PY  - 1998
SN  - 1367-4803
SP  - 157-163
T2  - BIOINFORMATICS
TI  - Rose: generating sequence families
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-16254026
Y2  - 2024-11-22T05:34:24
ER  -