TY - JOUR AB - Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months. DA - 2007 DO - 10.1186/1744-9081-3-14 LA - eng IS - 1 PY - 2007 SN - 1744-9081 T2 - Behavioral and Brain Functions TI - Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging UR - https://nbn-resolving.org/urn:nbn:de:0070-pub-16313048 Y2 - 2024-11-21T23:21:28 ER -