TY  - JOUR
AB  - Control of surface properties in microfluidic systems is an indispensable prerequisite for successful bioanalytical applications. Poly(dimethylsiloxane) (PDMS) microfluidic devices are hampered from unwanted adsorption of biomolecules and lack of methods to control electroosmotic flow (EOF). In this paper, we propose different strategies to. coat PDMS surfaces with poly(oxyethylene) (POE) molecules of varying chain lengths. The native PDMS surface is pretreated by exposure to UV irradiation or to an oxygen plasma, and the covalent linkage of POE-silanes as well as physical adsorption of a triblock-copolymer (F108) are studied. Contact angle measurements and atomic force microscopy (AFM) imaging revealed homogeneous attachment of POE-silanes and F108 to the PDMS surfaces. In the case of F108, different adsorption mechanisms to hydrophilic and hydrophobic PDMS are discussed. Determination of the electroosmotic mobilities of these coatings in PDMS microchannels prove their use for electrokinetic applications in which EOF reduction is inevitable and protein adsorption has to be suppressed.
DA  - 2005
DO  - 10.1021/la0510432
LA  - eng
IS  - 16
M2  - 7551
PY  - 2005
SN  - 0743-7463
SP  - 7551-7557
T2  - Langmuir
TI  - Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-17730891
Y2  - 2024-11-22T05:17:09
ER  -