TY  - JOUR
AB  - DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order of [lambda]- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium bistability between two different migration states, a slow one and a fast one. The latter can also be observed experimentally under appropriate conditions.
DA  - 2005
DO  - 10.1103/PhysRevE.71.011905
LA  - eng
IS  - 1
PY  - 2005
SN  - 1539-3755
T2  - Physical review, E
TI  - Two-state migration of DNA in a structured microchannel
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-17731105
Y2  - 2024-11-22T06:43:09
ER  -