TY  - JOUR
AB  - A conductance-based model for synaptic transmission and postsynaptic integration reveals how postsynaptic responses and their variability depend on the number of synaptic inputs. With increasing number of balanced stochastic excitatory and inhibitory inputs, the postsynaptic responses and their variance first increase and then decrease again. This non-linearity can be attributed to an anti-correlation between the total excitatory and inhibitory currents. The anti-correlation, which occurs even though the conductances of the individual synapses vary independently of each other, is determined by the total synaptic conductance and grows with the number of inputs. As the number of inputs increases, the membrane potential comes increasingly closer to the resting level.
DA  - 2003
DO  - 10.1016/S0925-2312(02)00797-X
KW  - Correlated synaptic currents
KW  - Number of inputs
KW  - Model
KW  - Graded synaptic transmission
KW  - Synaptic conductances
LA  - eng
M2  - 313
PY  - 2003
SN  - 0925-2312
SP  - 313-320
T2  - Neurocomputing
TI  - Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-17734497
Y2  - 2024-11-21T16:09:32
ER  -