TY - JOUR AB - Exploitation of recombinant organisms for the large-scale, commercial production of foreign proteins is often hampered by the problem of plasmid instability. A wide range of strategies have been reported for improving the stability of recombinant organisms. A combination of manipulating both the genetic design of recombinants and the conditions of culturing the organisms may be used to achieve stable host-vector associations during culture of recombinant organisms in bioreactors. DA - 1991 DO - 10.1016/0167-7799(91)90090-5 LA - eng IS - 1 M2 - 279 PY - 1991 SN - 0167-7799 SP - 279-284 T2 - Trends in biotechnology TI - Strategies for improving plasmid stability in genetically modified bacteria in bioreactors UR - https://nbn-resolving.org/urn:nbn:de:0070-bipr-32007 Y2 - 2024-11-21T22:29:57 ER -