TY  - JOUR
AB  - We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
DA  - 1990
DO  - 10.1007/BF01648890
KW  - HIV infection
KW  - Generalized likelihood ratio technique
KW  - Classification
KW  - T-cell subsets
KW  - Neopterin
LA  - eng
IS  - 1
M2  - 43
PY  - 1990
SN  - 0023-2173
SP  - 43-48
T2  - Journal of Molecular Medicine
TI  - Urinary neopterin concentrations and T-cell subset data in HIV-1 infection
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-17840537
Y2  - 2024-11-22T02:04:40
ER  -