TY  - THES
AB  - Conformational analysis by NMR spectroscopy and molecular dynamics simulations (MD) is one of the most important techniques for high resolution structure analysis in chemistry and biochemistry. In the frame of this thesis, a torsion angle based clustering procedure forms the basis of an enhanced methodology for conformational analysis by NMR and MD, the advantage of which is shown by comparison with prior procedures.
The determination of the structures of glycomimetic cyclic hexapeptides contributes to understanding the basis of the mimicry of the L2/HNK1 epitope, a carbohydrate structure with several important functions, in particular in the peripheral nervous system.
The structures of cyclic penta- and hexapapetides show the influence of the incorporated beta-homoamino acids on the structures of the peptides: A distinct preference for the central position of a pseudo-gamma-turn makes beta-homoamino acids suitable for the use as gamma-turn mimetics in rational peptide design.
DA  - 2006
KW  - Konformationsanalyse
KW  - Cluster-Analyse
KW  - Diederwinkel
KW  - Cyclopeptide
KW  - Aminosäuren (beta-)
KW  - Conformational analysis
KW  - Cluster analysis
KW  - Dihedral angle
KW  - Cyclic peptides
KW  - Beta-amino acids
LA  - ger
PY  - 2006
TI  - Effiziente Konformationsanalyse von Peptiden
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:361-8915
Y2  - 2024-11-21T22:38:56
ER  -