TY  - JOUR
AB  - A proof of concept for a one-pot process merging a heterocycle formation by a classical chemical approach at basic conditions with a biocatalytic reduction, running at neutral pH conditions, is reported. A crucial component for this process is the compartmentalization of the single reactions by the use of polydimethylsiloxane thimbles. This process was applied successfully towards an asymmetric synthesis of (S)-2,2,3-trimethyl-1-thia-4-azaspiro[4.4]nonane, leading to excellent enantioselectivities of 99% enantiomeric excess (ee).
DA  - 2018
DO  - 10.3390/bioengineering5030060
KW  - Asinger-type multi-component reaction
KW  - asymmetric synthesis
KW  - biocatalysis
KW  - cascades
KW  - compartmentalization
KW  - heterocycles
LA  - eng
IS  - 3
PY  - 2018
SN  - 2306-5354
T2  - Bioengineering
TI  - Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29302278
Y2  - 2024-11-22T07:13:02
ER  -