TY  - JOUR
AB  - Reaction conditions have been identified to conduct a one-pot asymmetric organocatalytic aldol reaction with a hydrophobic substrate in aqueous medium via a process running in flow mode. By employing a mixture of water and 2-propanol, a hydrophobic aldehyde and 3.6 mol% of an organocatalyst, this microreactor process affords the desired aldol adduct with a conversion of 74% and an enantioselectivity of 89% after a reaction time of 60 minutes.
DA  - 2019
DO  - 10.1055/s-0037-1610404
KW  - aldol reaction
KW  - asymmetric catalysis
KW  - continuously running processes
KW  - flow chemistry
KW  - organocatalysis
KW  - water
LA  - eng
IS  - 5
M2  - 1178
PY  - 2019
SN  - 0039-7881
SP  - 1178-1184
T2  - Synthesis
TI  - An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29343764
Y2  - 2024-11-22T01:07:54
ER  -