TY  - JOUR
AB  - Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and recurrence in a broad range of human cancers. Although being a key player in cancer development and progression by stimulating proliferation and metastasis and preventing apoptosis, the role of the transcription factor NF-κB in cancer stem cells is still underestimated. In the present review, we will evaluate the role of NF-κB in CSCs of glioblastoma multiforme, ovarian cancer, multiple myeloma, lung cancer, colon cancer, prostate cancer, as well as cancer of the bone. Next to summarizing current knowledge regarding the presence and contribution of CSCs to the respective types of cancer, we will emphasize NF-κB-mediated signaling pathways directly involved in maintaining characteristics of cancer stem cells associated to tumor progression. Here, we will also focus on the status of NF-κB-activity predominantly in CSC populations and the tumor mass. Genetic alterations leading to NF-κB activity in glioblastoma, ependymoma, and multiple myeloma will be discussed.
DA  - 2019
DO  - 10.3390/cancers11050655
KW  - cancer stem cells
KW  - NF-κB
KW  - glioblastoma multiforme
KW  - pediatric cancer
KW  - ovarian cancer
KW  - multiple myeloma
KW  - lung cancer
KW  - colon cancer
KW  - prostate cancer
KW  - bone cancer
LA  - eng
IS  - 5
PY  - 2019
SN  - 2072-6694
T2  - Cancers
TI  - A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29355949
Y2  - 2024-11-22T04:17:02
ER  -