TY  - THES
AB  - Among several achievements realised throughout this research, the highlight is the use of Deep eutectic solvents for one-pot chemoenzymatic cascades. Amine transaminases and alcohol dehydrogenases displayed praiseworthy performances in these neoteric solvents for the synthesis of bulky chiral compounds.
Besides the broadening of the substrate scope, a variety of of different enzymes has been tested for both cascade reactions. These results emphasize the value of nature’s biodiversity as an ever-increasing source of new genomes and metagenomes to identify unprecedented catalytic activities which can lead to novel robust biocatalysts. Furthermore medium engineering was demonstrated to be a valuable solution for the optimisation of chemical transformations and biocatalytic reactions with the possibility to overcome a set of hurdles and and reach improvement of the overall process.
DA  - 2019
LA  - eng
PY  - 2019
TI  - Combination of Suzuki cross-coupling reaction and biocatalysis in one-pot cascade processes
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29389947
Y2  - 2024-11-22T02:08:05
ER  -