TY  - JOUR
AB  - In the present study, we show how acrylamide-based microgels can be employed for the uptake and release of the drug beta-aescin, a widely used natural product with a variety of pharmacological effects. We show how aescin is incorporated into the microgel particles. It has an important influence on the structure of the microgels, by reducing their natural network-density gradient in the swollen state. Moreover, temperature-dependent measurements reveal how the incorporation of aescin stabilizes the microgel particles, while the volume phase transition temperature (VPTT) is almost constant, which is very important for the intended drug release. Finally, it is shown that upon increase of the temperature above the VPTT the particles are able to release aescin from their network, encouraging the use of this particular drug delivery system for hypothermia treatments.
DA  - 2020
DO  - 10.1007/s00396-020-04632-5
KW  - Microgels
KW  - Drug delivery
KW  - Biosurfactants
KW  - Saponins
KW  - Aescin
LA  - eng
M2  - 505–518
PY  - 2020
SN  - 0303-402X
SP  - 505–518-
T2  - Colloid and polymer science
TI  - Smart microgels as drug delivery vehicles for the natural drug aescin: uptake, release and interactions
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29427281
Y2  - 2024-11-22T05:39:01
ER  -