TY  - JOUR
AB  - A continuous-flow dynamic kinetic resolution of racemic secondary alcohols was carried out using a single column reactor packed with a mixture of immobilized lipase and an immobilized oxovanadium species, VMPS4. As a result, optically pure esters were produced in 88-92 % yields. Problems encountered in this study were overcome by using fillers that efficiently maintained the initial distribution of the catalysts in the reactor and by using a packing method in which the mixing ratio of the two catalysts was varied in a stepwise fashion. The flow process led to an increased turnover number of each catalyst compared to those of batch reactions.
DA  - 2020
DO  - 10.1002/ejoc.202000186
KW  - Lipase
KW  - Oxovanadium
KW  - Dynamic kinetic resolution
KW  - Flow reaction
KW  - Alcohols
LA  - eng
IS  - 13
M2  - 1961
PY  - 2020
SN  - 1434-193X
SP  - 1961-1967
T2  - European journal of organic chemistry
TI  - Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29428900
Y2  - 2024-11-22T05:14:53
ER  -