TY  - JOUR
AB  - As both, continuous synthesis and (bio-)catalysis gained increasing interest in research as well as for industrial applications, ways for merging these fields enables novel opportunities for modern sustainable process development. In this contribution, an alternative approach for the application of immobilized enzymes in continuous flow processes is presented utilizing heterogeneous biocatalysts as a mobile phase. Based on superabsorber-entrapped enzymes and whole cells as a "fluid heterogeneous phase", a segmented hydrogel/organic solvent system was developed. Its applicability was investigated with two entirely different model reaction systems, namely the alcohol dehydrogenase (ADH)-catalysed reduction of acetophenone, and the aldoxime dehydratase (Oxd)-catalysed dehydration of octanal oxime. In particular for solvent labile catalytic systems, this approach offers an alternative for the application of immobilized biocatalysts in a continuously running process beyond the "classic" packed bed and wall coated reactors.
DA  - 2020
DO  - 10.1002/ejoc.202000705
KW  - Biocatalysis
KW  - Flow chemistry
KW  - Heterogenous catalysis
KW  - Immobilisation
LA  - eng
M2  - 6062
PY  - 2020
SN  - 1434-193X
SP  - 6062-6067
T2  - European Journal of Organic Chemistry
TI  - Heterogeneous Catalysts "on the Move": Flow Chemistry with Fluid Immobilised (Bio)Catalysts
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29458359
Y2  - 2024-11-21T19:50:28
ER  -