TY  - JOUR
AB  - While belonging to the most fundamental functional groups, nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the synthesis of a range of nitrile products. In these biotransformations, the Oxd enzymes catalyze the dehydration of aldoximes as readily available substrates to the nitrile products. Herein, these developments with such enzymes are summarized, with a strong focus on synthetic applications. It is demonstrated that this biocatalytic technology has the potential to “cross the bridge” between the production of fine chemicals and pharmaceuticals, on one hand, and bulk and commodity chemicals, on the other.
DA  - 2021
DO  - 10.1002/chem.202001647
LA  - eng
IS  - 17
M2  - 5313
PY  - 2021
SN  - 0947-6539
SP  - 5313-5321
T2  - Chemistry – A European Journal
TI  - Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29531124
Y2  - 2024-11-22T10:01:01
ER  -