TY  - JOUR
AB  - Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery. Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous compared to in vivo assembly, because it avoids encapsidation of host-derived components and enables loading with added cargoes. This review provides an overview of ex cella VLP production methods focusing on capsid protein production, factors that impact the in vitro assembly, and approaches to characterize in vitro VLPs. The uses of in vitro produced VLPs as vaccines and for therapeutic delivery are also reported.
DA  - 2021
DO  - 10.3390/life11040334
KW  - capsid protein
KW  - in vitro assembly
KW  - virus-like particle
KW  - VLP-based vaccines
KW  - drug delivery
LA  - eng
IS  - 4
PY  - 2021
T2  - Life
TI  - In Vitro Assembly of Virus-Like Particles and Their Applications
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29540655
Y2  - 2024-11-24T14:47:33
ER  -