TY  - JOUR
AB  - Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases. Emerging evidence in the murine system suggests neuroprotective effects of blood plasma on the aged or diseased brain. However, little is known about plasma-mediated effects on human neurons. In the present study, we demonstrate the neuroprotective effect mediated by human plasma and the most abundant plasma–protein human serum albumin against oxidative stress in glutamatergic neurons differentiated from human neural crest-derived inferior turbinate stem cells. We observed a strong neuroprotective effect of human plasma and human serum albumin against oxidative stress-induced neuronal death on the single cell level, similar to the one mediated by tumor necrosis factor alpha. Moreover, we detected neuroprotection of plasma and human serum albumin against kainic acid-induced excitatory stress in ex vivo cultured mouse hippocampal tissue slices. The present study provides deeper insights into plasma-mediated neuroprotection ultimately resulting in the development of novel therapies for a variety of neurological and, in particular, neurodegenerative diseases.
DA  - 2021
DO  - 10.3390/ijms22179567
KW  - human blood plasma
KW  - neuroprotection
KW  - oxidative stress-induced neuronal death
KW  - human serum albumin
KW  - human neural crest-derived stem cells
LA  - eng
IS  - 17
PY  - 2021
T2  - International Journal of Molecular Sciences
TI  - Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons
UR  - https://nbn-resolving.org/urn:nbn:de:0070-pub-29573207
Y2  - 2024-11-22T09:14:52
ER  -