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Sreekumar, Sruthi ; Goycoolea, Francisco Martin ; Moerschbacher, Bruno ; Rivera-Rodriguez, Gustavo R.: Parameters influencing the size of chitosan-TPP nano- and microparticles
Inhalt
Materials.
Methods.
Production of Chitosans.
Characterization of Chitosans.
Table 1 Structural characteristics of the chitosans used.
Preparation of Chitosan Nanoparticles.
Design of Experiments.
Figure 1 Surface response for influence on average hydrodynamic diameter of particles with a molar ratio of 1.
Table 2 Design of Experiments with codified and non-codified factor levels for the full factorial design.
Transmission electron microscopy.
Figure 2 Surface response for influence on average hydrodynamic diameter of particles with a molar ratio of 1.
Figure 3 Influence of chitosan concentration on the average hydrodynamic diameter of particles prepared using DA 20% (■), DA 35% (), and DA 50% () with a NH2/PO4 ratio of 1.
Results and Discussion
Figure 4 Size distribution by intensity of chitosan-TPP particles prepared from chitosan samples at varying DA and concentration (black 0.
Figure 5 TEM micrographs of chitosan-TPP particles prepared from chitosan samples at varying DA and concentration with a NH2/PO4 molar ratio of 1.
Figure 6 Viscosimetry studies performed on chitosans with similar DA (35%) but varying DP (700, 1600, 2500).
Conclusion
Acknowledgements