Roessingh, Sanne ; Rosing, Mechthild; Marunova, Martina; Ogueta, Maite ; George, Rebekah; Lamaze, Angelique; Stanewsky, Ralf: Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA
Inhalt
- Removal of the antenna partially restores temperature synchronization of pyx3 mutant flies
- PYX reduces intracellular Ca2+ reporter signals during temperature cycles
- Constitutive activation of PYX expressing cells interferes with temperature synchronization
- PYX impacts PER expression in s-LNv and DN1 clock neurons during temperature cycles
- Synchronized period expression in the s-LNv maintains temperature-synchronized behavior
- Discussion
- Methods
- Fly strains
- Locomotor activity recording and analysis
- Immunocytochemistry experiments and image processing
- Bioluminescence recordings
- Statistics
- Reporting summary
- References
- References
- Acknowledgements
- Author contributions
- Competing interests
- ACKNOWLEDGEMENTS