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Bitard-Feildel, Tristan ; Kemena, Carsten ; Greenwood, Jenny M. ; Bornberg-Bauer, Erich ; Bornberg-Bauer, E. ; Bauer, Erich Bornberg-: Domain similarity based orthology detection
Inhalt
Methods
Creation and evaluation of the similarity measures
Domain similarity matrix
Cosine similarity (COS) measure
Maximal weight matching (MWM) measure
Adding domain order to the COS and MWM measures
Adding a weight to the COS and MWM measures
The protein domain content similarity measure as a pre-processing step for orthology
porthoDom
Collapsing of domain repeats
Results and discussion
Evaluation of the COS and MWM similarity measures
Evaluation of protein orthology detection
Conclusion
Additional file
Additional file 1
Competing interests
Authors' contributions
Acknowledgements
References