Berlandi, Johannes; Lin, Fang-Ju ; Ambrée, Oliver ; Rieger, Dirk ; Paulus, Werner; Jeibmann, Astrid: Swing Boat: Inducing and Recording Locomotor Activity in a "Drosophila melanogaster" Model of Alzheimer’s Disease
Inhalt
- MATERIALS AND METHODS
- Fly Husbandry
- Preparation of Activity Tubes
- Swing Boat Rotating Tube Device
- Activity Induction using Swing Boat Device
- Monitoring Locomotor Activity of Adult
- RNA Isolation and cDNA Synthesis
- Quantitative Real-Time PCR
- Immunohistochemistry
- Microscopy and Image Processing
- Statistics
- RESULTS
- Swing Boat Device can Induce Activity in Flies
- A42-Expressing Flies Display Abnormalities in Activity and Sleep
- Exercise Induced Effects in a Fly Model of Alzheimer's Disease
- DISCUSSION
- AUTHOR CONTRIBUTIONS
- FUNDING
- ACKNOWLEDGMENTS
- SUPPLEMENTARY MATERIAL
- REFERENCES