Kampmeier, Tim-Gerald ; Arnemann, Philip-Helge ; Heßler, Michael ; Seidel, Laura M.; Becker, Karsten ; Morelli, Andrea ; Rehberg, Sebastian ; Ertmer, Christian: Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock
Inhalt
- Animal care.
- Instrumentation.
- Surgical preparation.
- Inclusion criteria.
- Induction of septic shock.
- Randomization.
- Study protocol.
- Measurements.
- Analysed laboratory variables.
- End of protocol and autopsy.
- Electron microscopy.
- Statistical analysis.
- Data availability.
- Results
- Features of septic shock (prior to study drug infusion).
- Hemodynamic and oxygen transport variables (during study drug infusion).
- Table 1 Haemodynamics of the study groups during the 24-hour interventional period.
- Figure 1 Cumulative fluid amount of the study animals.
- Table 2 Metabolism, oxygenation and temperature of the study groups during the 24-hour interventional period.
- Figure 2 Cumulative norepinephrine amount of the study animals.
- Figure 3 Cumulative fluid requirements per hour.
- Figure 4 EMTI score of the study animals.
- Table 3 Parameters of organ function of the study groups during the 24-hour interventional period.
- Figure 5 Survival of the study animals.
- Discussion
- Conclusion
- Acknowledgements