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Hauschild, Gregor ; Rohn, Karl ; Engelhardt, Eva; Sager, Martin ; Hardes, Jendrik ; Gosheger, Georg: Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration
Inhalt
Methods
Study design
Blood collection
Tissue sampling
Ultrafiltration (collection of ISF)
HPLC analysis of serum, ISF and CSF
HPLC analysis of tissue samples
Pharmacokinetic and statistical analysis
Results
ISF values
Serum values
Serum and ISF values in comparison
PK/PD ratios
The UF-device
Discussion
Conclusions
Competing interests
Authors' contributions
Acknowledgments
Author details
References