Chen, Zhiquan ; Mohr, Annika; Heitplatz, Barbara ; Hansen, Uwe; Pascher, Andreas ; Brockmann, Jens G.; Becker, Felix: Sulforaphane Elicits Protective Effects in Intestinal Ischemia Reperfusion Injury
Inhalt
- Results
- SFN Treated Mice were Less Susceptible to Intestinal IRI
- SFN Ameliorated IRI-Elicited Leukocyte and Platelet Recruitment
- SFN Treatment Decreased IRI-Elicited Neutrophil Infiltration in Intestinal Tissue without Altering Expression of Endothelial Adhesion Molecules
- SFN Reduced IRI-Elicited Ultrastructural Damage in the Intestine Protect Intestinal Barrier Integrity
- SFN Treated Mice were Less Prone to Altered Mucosal Permeability of the Small Bowel
- Discussion
- Materials and Methods
- Ethical Approval
- Animals
- Experimental Groups and Treatment
- In Vivo Model of Intestinal IRI
- Ex Vivo Platelet Preparation
- In Vivo Leukocyte Staining and Fluorescence Intravital Microscopy (IVM)
- Offline Video Analysis
- Intestinal Histology
- Electron Microscope
- Intestinal Tissue Myeloperoxidase (MPO) Activity
- Intestinal Mucosal Permeability
- Quantitative Polymerase Chain Reaction (qPCR)
- Statistics
- References