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Hofschröer, Verena; Najder, Karolina ; Rugi, Micol; Bouazzi, Rayhana; Cozzolino, Marco; Arcangeli, Annarosa; Panyi, Gyorgy; Schwab, Albrecht: Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy
Inhalt
Regulation of Pancreatic Cancer Cell Behavior by Ion Channels
K+ Channels in Pancreatic Cancer Cells
TRP Channels in Pancreatic Cancer Cells
Cl− Channels in Pancreatic Cancer Cells
Ion Channel Involvement in Desmoplasia
Pancreatic Stellate Cells
Ion Channels and Fibrosis
Immunity and PDAC
Ionic Composition of the Tumor Microenvironment
Cells of the Innate Immune Response
Cells of the Adaptive Immune Response
Adaptive Immunity: Antitumor Cells
Adaptive Immunity: Protumor Cells
Therapeutical Approaches and Ion Channels in PDAC
Electrolytes and Organic Metabolites in PDAC
Pharmacological Targeting of Ion Channels in PDAC
Challenges of Using KV11 Channels as Therapeutic Target in PDAC
Outlook
Author Contributions
Funding
Acknowledgments
References