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Jürgens, Franziska M.; Herrmann, Fabian C. ; Herrmann, Fabian Christopher ; Robledo, Sara M.; Schmidt, Thomas J.: Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture
Inhalt
Materials and Methods
Chemicals and Materials
Synthesis of Helenalin 3,4-Dimethoxycinnamate (H-DMCA)
Dermal Absorption Experiments
UHPLC-HRMS Analysis
UHPLC-HRMS Method Validation
UHPLC-FLD Analysis
Microscopy
Results and Discussion
Characterization of Arnica Tincture
Dermal Absorption of Arnica Tincture
Metabolic Activity of Skin Samples
Synthesis and Characterization of a Fluorescence-Labeled Sesquiterpene Lactone
Dermal Absorption Experiments with the Fluorescence-Labeled Sesquiterpene Lactone
Microscopic Analysis of Skin Penetration
Conclusions
References