Detzner, Johanna ; Pohlentz, Gottfried; Müthing, Johannes: Valid Presumption of Shiga Toxin-Mediated Damage of Developing Erythrocytes in EHEC-Associated Hemolytic Uremic Syndrome
Inhalt
- Hematopoiesis
- Erythropoiesis
- Ex Vivo Generation of Developing Erythrocytes
- Blood Transfusion
- Ex Vivo Generation of Cells of the Erythroid Lineage
- Dynamics of Erythropoietic Markers Glycophorin A, CD36, and CD45
- Biotechnological Aspects
- Mature and Developing Erythrocytes as Targets for Pathogens and Bacterial Toxins
- Pathogens That Target Human Mature or Developing Red Blood Cells
- Bacterial Toxins That Target Human Mature or Developing Red Blood Cells
- A Short Historical Reflection on Glycosphingolipids of Mature and Developing Erythrocytes
- Glycosphingolipids of Human Red Blood Cells
- Glycosphingolipids of Human Myeloid and Lymphoid Cells and Cell Lines
- Erythroid Character and Glycosphingolipid Expression of the Human Erythroleukemic K562 and HEL Cell Lines
- EHEC-Caused Diseases and Damage of Human Target Cells
- Shiga Toxin as Primordial Bacterial Weapon Against Eukaryotic Predators
- EHEC-Caused Life-Threatening Diseases
- Shiga Toxin and Toxin-Mediated Cell Damage
- Structure of Stx and Enzymatical Depurination of Ribosomal RNA and Nuclear DNA
- Stx Binding Specificity of the Inherent B Pentamer
- Interaction of the A Subunit of Stx with the Toll-like Receptor 4
- Retrograde Transport of Stx
- Human Target Cells of Shiga Toxins
- Erythrocyte Morphology in the Microcirculation and Hemolysis
- Direct Shiga Toxin-Mediated Injury of Developing Human Erythrocytes
- Ex Vivo Amplification and Maturation of CD34+ Hematopoietic Stem/Progenitor Cells
- CD34+ HSPCs and Stem Cell Mobilization
- Cytokine-Induced Ex Vivo Amplification and Differentiation of Erythroid Cells
- Morphological Alterations of Developing Erythrocytes
- Synopsis of Morphological Shifts During Ex Vivo Erythropoiesis
- Shiga Toxin-Mediated Damage of Erythroblasts During Erythropoiesis
- Globo-Series Glycosphingolipids of Human Erythropoietic Cells
- Glycosphingolipid Expression during Human Stem Cell Differentiation
- Glycosphingolipid Expression of Human Erythroid Cells
- Glycosphingolipid Expression of Ex Vivo Amplified Primary Human Erythropoietic Cells
- Shiga Toxin 2a-Mediated Cell Damage and Toxin Receptors of Ex Vivo-Propagated Erythropoietic Cells
- Conclusions and Outlook
- References