Chemical sites are an integral part of the chemical industry in Germany. Therefore, it is obvious that the development from diversified to more specialized chemical companies will also lead to rising challenges for the chemical siting sector. Furthermore, chemical sites need to react to changes in the environment of chemical companies, such as the relocation of supply chains or intensifying EU regulations. As changes in the chemical industry require the adaptation of chemical sites, this article presents a study design to assess the status quo and the future challenges chemical sites will need to confront.