The chemical industry is one of the biggest and most impactful sectors in society. Apart from its economic importance in terms of revenue and employment (CEFIC, 2018), it also plays a crucial role in the way mankind uses renewable and non-renewable resources now and in the future. Climate change, biodiversity challenges and waste pollution can only truly be tackled with the chemical industry as a partner. This means that the industry itself has to transition away from old and sometimes obsolete paradigms and ways of working. This paper suggests where and how to situate this change and presents essential mechanisms and concepts to help realize that change. The solution framework encompasses insights in environmental economics, new financial and non-financial valuation rules, different and more holistic leadership styles and specific technical levers. The aim is to trigger the reader’s curiosity to find out more about the aforementioned ingredients and to launch a call to action to start exploring and experimenting. The time is now (Webster, 2017).