TY  - JOUR
AB  - The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine samples from brain-dead (n = 30) and living related (n = 50) donors and their corresponding recipients were analyzed before and after kidney transplantation. Urine α- and π-GST values were measured. Kidney recipients were grouped into patients with acute graft rejection (AGR), calcineurin inhibitor toxicity (CNI), and delayed graft function (DGF), and compared to those with unimpaired graft function. Urinary π-GST revealed significant differences in deceased kidney donor recipients with episodes of AGR or DGF at day one after transplantation (p = 0.0023 and p = 0.036, respectively). High π-GST values at postoperative day 1 (cutoff: >21.4 ng/mg urine creatinine (uCrea) or >18.3 ng/mg uCrea for AGR or DGF, respectively) distinguished between rejection and no rejection (sensitivity, 100%; specificity, 66.6%) as well as between DGF and normal-functioning grafts (sensitivity, 100%; specificity, 62.6%). In living donor recipients, urine levels of α- and π-GST were about 10 times lower than in deceased donor recipients. In deceased donors with impaired graft function in corresponding recipients, urinary α- and π-GST were elevated. α-GST values >33.97 ng/mg uCrea were indicative of AGR with a sensitivity and specificity of 77.7% and 100%, respectively. In deceased donor kidney transplantation, evaluation of urinary α- and π-GST seems to predict different events that deteriorate graft function. To elucidate the potential advantages of such biomarkers, further analysis is warranted.
AU  - Katou, Shadi
AU  - Globke, Brigitta
AU  - Morgul, M. Haluk
AU  - Vogel, Thomas
AU  - Strücker, Benjamin
AU  - Otto, Natalie Maureen
AU  - Reutzel-Selke, Anja
AU  - Marksteiner, Marion
AU  - Brockmann, Jens G.
AU  - Pascher, Andreas
AU  - Schmitz, Volker
DA  - 2019-11-07
DO  - 10.3390/jcm8111899
KW  - kidney transplantation
KW  - urinary biomarkers
KW  - α-GST
KW  - π-GST
KW  - acute rejection
KW  - delayed graft function
KW  - nephrotoxicity
LA  - eng
N1  - Journal of Clinical Medicine 8 (2019) 11, 1899, 1-11
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster)
PY  - 2019-11-07
TI  - Urinary Biomarkers α-GST and π-GST for Evaluation and Monitoring in Living and Deceased Donor Kidney Grafts
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-78079561527
Y2  - 2024-11-22T02:27:41
ER  -