TY  - JOUR
AB  - Background: Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these immunologic factors remains unclear. Method: The impact of both factors was evaluated in a study collective of 321 clinically well-annotated patients with non-small lung cancer (NSCLC) using immunohistochemistry. Results: PD-1 expression by tumor infiltrating lymphocytes (TILs) was found in 22%, whereas tumor cell associated PD-L1 expression was observed in 24% of the NSCLC tumors. In Fisher’s exact test a positive correlation was found for PD-L1 and Bcl-xl protein expression (p = 0.013). Interestingly, PD-L1 expression on tumor cells was associated with improved overall survival in pulmonary squamous cell carcinomas (SCC, p = 0.042, log rank test), with adjuvant therapy (p = 0.017), with increased tumor size (pT2-4, p = 0.039) and with positive lymph node status (pN1-3, p = 0.010). These observations were confirmed by multivariate cox regression models. Conclusion: One major finding of our study is the identification of a prognostic implication of PD-L1 in subsets of NSCLC patients with pulmonary SCC, with increased tumor size, with a positive lymph node status and NSCLC patients who received adjuvant therapies. This study provides first data for immune-context related risk stratification of NSCLC patients. Further studies are necessary both to confirm this observation and to evaluate the predictive value of PD-1 and PD-L1 in NSCLC in the context of PD-1 inhibition.
AU  - Schmidt, Lars Henning
AU  - Kümmel, Andreas
AU  - Görlich, Dennis
AU  - Mohr, Michael
AU  - Bröckling, Sebastian
AU  - Mikesch, Jan-Henrik
AU  - Grünewald, Inga
AU  - Marra, Alessandro
AU  - Schultheis, Anne Maria
AU  - Müller-Tidow, Carsten
AU  - Spieker, Georg Tilmann
AU  - Schliemann, Christoph
AU  - Berdel, Wolfgang E.
AU  - Berdel, Wolfgang
AU  - Berdel, W. E.
AU  - Wiewrodt, Rainer Gerhard
AU  - Wiewrodt, Rainer
AU  - Hartmann, Wolfgang
DA  - 2015-08-27
DO  - 10.1371/journal.pone.0136023
LA  - eng
N1  - PLoS ONE 10 (2015) 8, e0136023, 1-15
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2015-08-27
SN  - 1932-6203
TI  - PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-07269496604
Y2  - 2024-11-22T03:00:33
ER  -