TY  - JOUR
AB  - Circadian clocks are endogenous molecular oscillators that temporally organize behavioral activity thereby contributing to the fitness of organisms. To synchronize the fly circadian clock with the daily fluctuations of light and temperature, these environmental cues are sensed both via brain clock neurons, and by light and temperature sensors located in the peripheral nervous system. Here we demonstrate that the TRPA channel PYREXIA (PYX) is required for temperature synchronization of the key circadian clock protein PERIOD. We observe a molecular synchronization defect explaining the previously reported defects of pyx mutants in behavioral temperature synchronization. Surprisingly, surgical ablation of pyx-mutant antennae partially rescues behavioral synchronization, indicating that antennal temperature signals are modulated by PYX function to synchronize clock neurons in the brain. Our results suggest that PYX protects antennal neurons from faulty signaling that would otherwise interfere with temperature synchronization of the circadian clock neurons in the brain.
AU  - Roessingh, Sanne
AU  - Rosing, Mechthild
AU  - Marunova, Martina
AU  - Ogueta, Maite
AU  - George, Rebekah
AU  - Lamaze, Angelique
AU  - Stanewsky, Ralf
DA  - 2019-07-01
DO  - 10.1038/s42003-019-0497-0
KW  - Circadian rhythms and sleep
KW  - Ion channels in the nervous system
LA  - eng
N1  - Communications Biology 2 (2019) 246, 1-13
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - This work was supported by the European Union FP7 Integrated Training Network INsecTIME and the EU H2020 ITN CINCHRON.
PY  - 2019-07-01
TI  - Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-82119445267
Y2  - 2024-12-27T09:02:42
ER  -