TY  - JOUR
AB  - Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox·HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox·Lipo), two common drugs for anti-cancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues.
AU  - Kimm, Melanie Alexandra
AU  - Groß, Claudia Maria
AU  - Dean-Ben, Xose Luis
AU  - Ron, Avihai
AU  - Rummeny, Ernst-Josef
AU  - Rummeny, Ernst Josef
AU  - Rummeny, Ernst J.
AU  - Rummeny, Ernst-J.
AU  - Rummeny, E. J.
AU  - Lin, Hsaio-Chun Amy
AU  - Höltke, Carsten
AU  - Razansky, Daniel
AU  - Wildgruber, Moritz
DA  - 2019-05-31
DO  - 10.1371/journal.pone.0217576
LA  - eng
N1  - PLoS ONE 14 (2019) 5, e0217576, 1-11
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2019-05-31
TI  - Optoacoustic properties of Doxorubicin – A pilot study
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-82119404758
Y2  - 2024-11-22T00:22:40
ER  -