TY  - JOUR
AB  - BACKGROUND: Transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with severe aortic valve stenosis who are not eligible for operative replacement and an alternative for those with high surgical risk. Due to high age and smoking history in a high proportion of TAVI patients, suspicious findings are frequently observed in pre-procedural chest computer tomography (CCT). METHODS: CCT scans of 484 consecutive patients undergoing TAVI were evaluated for incidentally discovered solitary pulmonary nodules (SPN). RESULTS: In the entire study population, SPN ≥ 5 mm were found in 87 patients (18%). These patients were compared to 150 patients who were incidentally collected from the 397 patients without SPN or with SPN < 5 mm (control group). After a median follow-up of 455 days, lung cancer was diagnosed in only two patients. Neither SPN ≥ 5 mm (p = 0.579) nor SPN > 8 mm (p = 0.328) were significant predictors of overall survival. CONCLUSIONS: Despite the high prevalence of SPNs in this single center TAVI cohort lung cancer incidence at midterm follow-up seems to be low. Thus, aggressive diagnostic approaches for incidentally discovered SPN during TAVI evaluation should not delay the treatment of aortic stenosis. Unless advanced thoracic malignancy is obvious, the well documented reduction of morbidity and mortality by TAVI outweighs potentially harmful delays regarding further diagnostics. Standard guideline-approved procedure for SPN can be safely performed after TAVI.
AU  - Schmidt, Lars Henning
AU  - Vietmeier, Benedikt
AU  - Kaleschke, Gerrit Tobias
AU  - Schülke, Christoph
AU  - Görlich, Dennis
AU  - Schliemann, Christoph
AU  - Keßler, Torsten
AU  - Schulze, Arik Bernard
AU  - Buerke, Boris Tobias
AU  - Buerke, Boris
AU  - Kümmel, Andreas
AU  - Thrull, Michael
AU  - Wiewrodt, Rainer Gerhard
AU  - Wiewrodt, Rainer
AU  - Baumgartner, Helmut
AU  - Berdel, Wolfgang E.
AU  - Berdel, Wolfgang
AU  - Berdel, W. E.
AU  - Mohr, Michael
DA  - 2016-05-12
DO  - 10.1371/journal.pone.0155398
LA  - eng
N1  - PLoS ONE 11 (2016) 5, e0155398, 1-14
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2016-05-12
SN  - 1932-6203
TI  - Thoracic Malignancies and Pulmonary Nodules in Patients under Evaluation for Transcatheter Aortic Valve Implantation (TAVI): Incidence, Follow Up and Possible Impact on Treatment Decision
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-24269609381
Y2  - 2024-11-22T00:59:29
ER  -