TY  - JOUR
AB  - Background: Immunosuppression, denervation of biliary tract, and presence of biliary strictures favor colonization of bile with microorganisms after liver transplantation. Little is known about spectrum and antibiotic susceptibility of this colonization. Material and Methods: Bile and feces were collected prospectively from 38 patients who underwent endoscopic retrograde cholangiopancreaticography after liver transplantation. Samples were analyzed for colonization and antibiotic susceptibility. Results: From the 38 tested bile samples, 86.6% tested positive. Of those, 26 (78.8%) were polymicrobial. Of isolated bile samples, 52 (64.2%) were gram-positive, 22.2% were gram-negative, and 13.6% revealed Candida albicans. Most detectable gram-positive bacteria were Enterococcus faecium. Most detectable gram-negative bacteria were E. coli and Klebsiella pneumonia. Our analyses revealed high resistance rates of the isolates. Only 55.6% of isolates were sensitive to ciprofloxacin, 54% were sensitive to piperacillin/tazobactam, and 60.3% were sensitive to imipenem. High susceptibility rates were found for linezolid and vancomycin (72.9% and 72.6%, respectively). We found a high correlation between microorganisms found in bile and those isolated from stool. Conclusions: Bile of liver transplant recipients is frequently colonized with microorganisms. The starting point of this colonization is usually the intestine. Systematic analysis of bile colonization during endoscopic interventions on biliary tracts of liver transplant recipients might help to select effective prophylactic antibiotic regimes as well as to facilitate the choice of suitable antimicrobial therapy in case of septic complications.
AU  - Kabar, Iyad
AU  - Hüsing, Anna Katharina Elisabeth Pia
AU  - Cicinnati, Vito R.
AU  - Heitschmidt, Laura
AU  - Heitschmidt, Laura Johanna Katharina
AU  - Beckebaum, Susanne
AU  - Thölking, Gerold Bernhard
AU  - Schmidt, Hartmut
AU  - Karch, Helge
AU  - Kipp, Frank
DA  - 2015-05-04
DO  - 10.12659/AOT.893549
KW  - Bile Duct Diseases
KW  - Cholangiopancreatography
KW  - Endoscopic Retrograde
KW  - Liver Transplantation
LA  - eng
N1  - Annals of Transplantation 20 (2015), 249-255
N1  - Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2015-05-04
TI  - Analysis of Bile Colonization and Intestinal Flora may Improve Management in Liver Transplant Recipients Undergoing ERCP
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-69249637696
Y2  - 2024-11-21T22:59:03
ER  -