TY  - JOUR
AB  - Alterations of Eph receptor tyrosine kinases are frequent events in human cancers. Genetic variations of EPHB6 have been described but the functional outcome of these alterations is unknown. The current study was conducted to screen for the occurrence and to identify functional consequences of EPHB6 mutations in non-small cell lung cancer. Here, we sequenced the entire coding region of EPHB6 in 80 non-small cell lung cancer patients and 3 tumor cell lines. Three potentially relevant mutations were identified in primary patient samples of NSCLC patients (3.8%). Two point mutations led to instable proteins. An in frame deletion mutation (del915-917) showed enhanced migration and accelerated wound healing in vitro. Furthermore, the del915-917 mutation increased the metastatic capability of NSCLC cells in an in vivo mouse model. Our results suggest that EPHB6 mutations promote metastasis in a subset of patients with non-small cell lung cancer.
AU  - Bulk, Etmar Michael
AU  - Yu, Jun
AU  - Hascher, Antje
AU  - Koschmieder, Steffen
AU  - Wiewrodt, Rainer Gerhard
AU  - Wiewrodt, Rainer
AU  - Krug, Utz
AU  - Timmermann, Bernd
AU  - Marra, Alessandro
AU  - Hillejan, Ludger
AU  - Müller-Tidow, Carsten
DA  - 2012-12-04
DO  - 10.1371/journal.pone.0044591
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - PLOS ONE 7 (2012) 12, e44591
PY  - 2012-12-04
TI  - Mutations of the EPHB6 Receptor Tyrosine Kinase Induce a Pro-Metastatic Phenotype in Non-Small Cell Lung Cancer
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-37379422304
Y2  - 2024-11-22T05:27:45
ER  -