TY  - JOUR
AB  - Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.
AU  - Schröder, Olga
AU  - Schriewer, Elisabeth
AU  - Golombeck, Kristin
AU  - Kürten, Julia
AU  - Lohmann, Hubertus
AU  - Schwindt, Wolfram
AU  - Wiendl, Heinz
AU  - Wiendl, H.
AU  - Bruchmann, Maximilian
AU  - Schmidt, Maximilian
AU  - Melzer, Nico
AU  - Straube, Thomas
DA  - 2015-11-30
DO  - 10.3389/fneur.2015.00250
KW  - amygdala
KW  - limbic encephalitis
KW  - emotion processing
KW  - dynamic stimulus material
KW  - skin conductance
LA  - eng
N1  - Frontiers in Neurology 6 (2015) 250, 1-8
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2015-11-30
SN  - 1664-2295
TI  - Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-37249627693
Y2  - 2024-11-22T01:59:00
ER  -