TY  - JOUR
AB  - Dysphagia can be predominant or sole symptom of myositis. However, diagnostic evaluation is difficult in such cases. Here, we present evidence for dysphagia as sole manifestation of Jo-1 associated myositis. A 77-year-old patient suffering from isolated dysphagia was assessed by flexible endoscopic evaluation of swallowing, videofluoroscopy, high resolution esophageal manometry, whole body muscle MRI, electroneurographic and electromyographic examination, cerebrospinal fluid analysis, screening for autoantibodies, and body plethysmography. We detected isolated oropharyngeal dysphagia including a decreased pressure of the upper esophageal sphincter leading to cachexia in an anti-Jo-1 positive patient without any abnormalities in the other diagnostics. Immunosuppressive therapy with cortisone and azathioprine led to long-term improvement of dysphagia. This is the first report of isolated dysphagia as manifestation of Jo-1 associated myositis. Therefore, Jo-1 associated myositis should be considered as a possible differential diagnosis for isolated dysphagia. Typical signs for myositis in instrumental dysphagia assessment are presented.
AU  - Labeit, Bendix
AU  - Muhle, Paul
AU  - Suntrup, Sonja
AU  - Ahring, Sigrid
AU  - Ruck, Tobias
AU  - Dziewas, Rainer
AU  - Warnecke, Tobias
DA  - 2019-07-09
DO  - https://doi.org/10.3389/fneur.2019.00739
KW  - dysphagia
KW  - myositis
KW  - antisynthetase syndrome
KW  - antisynthetase antibody
KW  - Jo-1
KW  - Jo-1 autoantibody
KW  - diagnostic algorithm
KW  - idiopathic inflamed myopathy
LA  - eng
N1  - Frontiers in Neurology 10 (2019) 739, 1-5
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2019-07-09
TI  - Dysphagia as Isolated Manifestation of Jo-1 Associated Myositis?
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-92109499082
Y2  - 2024-11-22T04:33:55
ER  -