TY  - JOUR
AB  - Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural properties and functionality. EspP has been used to investigate mechanistic details of autotransport, and recent studies indicate that this transport mechanism is not autonomous but rather dependent on additional factors. Currently, five subtypes have been identified (EspPα-EspPε), with EspPα being associated with highly virulent EHEC serotypes and isolates from patients with severe disease. EspPα has been shown to degrade major proteins of the complement cascade, namely C3 and C5 and probably interferes with hemostasis by cleavage of coagulation factor V. Furthermore, EspPα is believed to contribute to biofilm formation perhaps by polymerization to rope-like structures. Together with the proteolytic activity, EspPα might ameliorate host colonization and interfere with host response.
AU  - Weiss, André
AU  - Brockmeyer, Jens
DA  - 2012-12-28
DO  - 10.3390/toxins5010025
KW  - EspP
KW  - EHEC
KW  - virulence factor
KW  - SPATE
KW  - autotransporter
KW  - serine protease
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - Toxins 5 (2013) 1, 25-48
PY  - 2012-12-28
TI  - Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-17379538914
Y2  - 2024-11-22T02:28:08
ER  -