TY  - JOUR
AB  - The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca2+ binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.
AU  - Heßner, Florian
AU  - Dlugos, Christopher Philipp Gerhard
AU  - Chehab, Tarek
AU  - Schaefer, C.
AU  - Homey, B.
AU  - Gerke, Volker
AU  - Weide, Thomas
AU  - Pavenstädt, Hermann-Joseph
AU  - Rescher, Ursula
DA  - 2016-03-04
DO  - 10.1038/srep22649
LA  - eng
N1  - Scientific Reports 6 (2016) 22649, 1-9
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2016-03-04
SN  - 2045-2322
TI  - CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-45289604790
Y2  - 2024-11-22T02:23:19
ER  -