TY  - JOUR
AB  - Background: Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil. Methods: The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain. Results: Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices. Conclusions: Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested.
AU  - Karimzadeh, Fariba
AU  - Hosseini, Mahmoud
AU  - Mangeng, Diana
AU  - Alavi, Hassan
AU  - Hassanzadeh, Gholam Reza
AU  - Bayat, Mohamad
AU  - Jafarian, Maryam
AU  - Weyssari, Hadi K.
AU  - Weyssari, Hadi Kazemi
AU  - Kazemi Weyssari, Hadi
AU  - Kazemi-Weyssari, Hadi
AU  - Gorji, Ali
DA  - 2012-06-18
DO  - doi:10.1186/1472-6882-12-76
KW  - Cephalic pain
KW  - Stroke
KW  - Brain ischemia
KW  - Medical plants
KW  - Traditional therapy
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - BMC Complementary and Alternative Medicine 12 (2012) 76.
PY  - 2012-06-18
TI  - Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-47369423148
Y2  - 2024-11-22T00:22:38
ER  -